Moosehead Lake is a Reservoir in Piscataquis, Maine.

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Moosehead Lake is the largest lake in the U.S. state of Maine. Situated in the Longfellow Mountains in the Maine Highlands Region, the lake is the source of the Kennebec River. Towns that border the lake include Greenville to the south and Rockwood to the northwest. There are over 80 islands in the lake, the largest being Sugar Island.

Set at an elevation of 1,023 feet (312 m), Moosehead Lake is approx. 40 by 10 miles (64 by 16 km), with an area of 120 mile² (311 km²), and over 400 miles (640 km) of shoreline. Its major inlet is the Moose River, which, east of Jackman, flows through Long Pond to Brassua Lake. To the east of Moosehead Lake, the Roach River is its second largest tributary. Flowing out of Moosehead Lake to the southwest are its east and west outlets -- the Kennebec River.

The Moosehead Lake Region encompasses 4,400 square miles (11,000 km²) of West Central Maine, and includes 127 townships in addition to Moosehead Lake. The region is drained by 330 miles (530 km) of main stem rivers, into which flow 3,850 miles (6,200 km) of smaller tributaries. During the last glacial era, more than 1,200 natural lakes and ponds were carved into its landscape, varying in size from one acre (4,000 m²) ponds to Moosehead, at 74,890 acres (303 km²) one of the largest natural freshwater lakes in the United States. The total area of all standing surface waters in the region is more than 238,000 acres (963 km²) -- 24% of the total area of lakes and ponds in Maine.